研究成果

 

(一)发表论文(近五年)

张国君(英文,#:通讯作者,##:并列通讯作者,*:第一作者或并列第一作者)

1.Zhu XS, Zhang B, Zhao HY, Dou XW, Bai JW & Zhang GJ#. Jagged-2 enhances immunomodulatory activity in adipose derived mesenchymal stem cells. Scientific Reports, 2015, 5:14284.

2.Peng HW, Wang SJ, Niu XH, Yang XH, Chi CW, Zhang GJ#. Sentinel node biopsy using indocyanine green in oral/oropharyngeal cancer. World Journal of Surgical Oncology, 2015, 13(1):278.

3.Zhang YQ, Wei XL, Liang YK, Chen WL, Zhang F, Bai JW, Qiu SQ, Du CW, Huang WH##, Zhang GJ##. Over-Expressed Twist Associates with Markers of Epithelial Mesenchymal Transition and Predicts Poor Prognosis in Breast Cancers via ERK and Akt Activation. PLoS One, 2015, 10(8):e0135851.

4.Hong CQ, Zhang F, You YJ, Qiu WL, Giuliano AE, Cui XJ, Zhang GJ, Cui YK. Elevated C1orf63 expression is correlated with CDK10 and predicts better outcome for advanced breast cancers: a retrospective study. BMC Cancer. 2015, 15:548.

5.He DE, Bai JW, Liu J, DU CW, Huang WH, Zhang GJ#. Clinicopathological characteristics and prognosis of breast cancer patients with type 2 diabetes mellitus. Mol Clin Oncol, 2015,3(3):607-612.

6.Li YK*, Zheng Y, Lin JB, Xu GX, Cai AQ, Zhou XG, Zhang GJ#. CT imaging of ovarian yolk sac tumor with emphasis on differential diagnosis. Scientific Reports, 2015, 5:11000.

7.Wei XL, Dou XW, Bai JW, Luo XR, Qiu SQ, Xi DD, Huang WH, Du CW, Man K, Zhang GJ#. ERα inhibits epithelial-mesenchymal transition by suppressing Bmi1 in breast cancer. Oncotarget, 2015, 6(25):21704-17.

8.Fu XJ, Shi XJ, Lin K, Lin H, Huang WH, Zhang GJ##, Au WW##. Environmental and DNA repair risk factors for breast cancer in South China. International Journal of Hygiene and Environmental Health, 2015, 218(3):313-8.

9.Liang SX, Peng X, Li XL, Yang P, Xie LH, Li YC, Du CW, Zhang GJ##. Silencing of CXCR4 sensitizes triple-negative breast cancer cells to cisplatin. Oncotarget, 2015, 6(2):1020-1030.

10.Wei XL, Zhang DH, Dou XW, Niu N, Bai JW, Huang WH and Zhang GJ#. Elevated 14, 15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer. BMC Cancer, 2014, 14:841.

11.Wei XL, Chen CF, Xi DD, Bai JW, Huang WH, Rong LX, Wu MY, Zhang GJ#.A case of primary neuroendocrine breast carcinoma that responded to neo-adjuvant chemotherapy. Frontiers of Medicine, 2014.

12.Liu J, Shen JX, Hu JL, Huang WH and Zhang GJ#. Significance of interleukin-33 and its related cytokines in patients with breast cancers. Frontiers in Immunology, 2014, 5:141.

13.Huang WH, Qiu SQ, Wu JD, Du CW, Cui YK and Zhang GJ*. Analysis of Clinicopathological Characteristics and Prognosis of 1425 Primary Breast Cancer Patients in Eastern Guangdong, China. Current Signal Transduction Therapy, 2014, 9(1):44-49.

14.Wei JT, Huang WH, Du CW, QIU SQ, Wei XL, Liu J, Zhang GJ#. Clinicopathological features and prognostic factors of young breast cancers in Eastern Guangdong of China. Scientific Reports, 2014, 4:5360.

15.Yang P, Liang SX, Huang WH, Zhang HW, Li XL, Xie LH, Du CW, Zhang GJ##. Aberrant expression of CXCR4 significantly contributes to metastasis and predicts poor clinical outcome in breast cancer. Current Molecular Medicine. 2014, 14(1):174-84.

16.Wu JD, Huang WH, Huang ZY, Chen M and Zhang GJ#. Brachial plexus palsy after a left-side modified radical mastectomy with immediate latissimusdorsi flap reconstruction: report of a case. World Journal of Surgical Oncology, 2013, 11:276.

17.Chi CW, Ye JZ, Ding HL, He D, Huang WH, Zhang GJ##, Tian J. Use of Indocyanine Green for Detecting the SentinelLymph Node in Breast Cancer Patients: From Preclinical Evaluation to Clinical Validation. PLoS one, 2013, 8(12): e83927.

18.Chen SF, Du CW, Yang P, Zhang HW, Man K and Zhang GJ##. The molecular and clinicopathologic characteristics of bilateral breast cancer. Scientific Reports, 2013, 3:2590.

19.Qiu SQ, Wei XL, Huang WH, Wu MY, Qin YS, Li YK and Zhang GJ#. Diagnostic and therapeutic strategy and the most efficient prognostic factors of breast malignant fibrous histiocytoma. Scientific Reports, 2013, 3:2529.

20.Yang P, Du CW, Man K, Liang SX and Zhang GJ##. The impact of p53 in predicting clinical outcome of breast cancer patients with visceral metastasis. Scientific Reports, 2013,3:2246.

21.Xu HW, Huang YJ, Xie ZY, Lin L, Guo YC, Zhuang ZR, Lin XP, Zhou W, Mu L, Huang HH, Wei XL, Man K and Zhang GJ##. The expression of cytoglobin as a prognostic factor in gliomas:a retrospective analysis of 88 patients. BMC Cancer, 2013, 13:247.

22.Chen M, Cui YK, Huang WH, Man K and Zhang GJ#. Phosphorylation of estrogen receptor α at serine 118 is correlated with breast cancer resistance to tamoxifen, Oncology Letters, 2013, 6(1):118-124.

23.Ma CC, Wang Y, Zhang GJ, Chen ZS, Qiu YM, Li J, Luo J, Huang BH, Jiang CF, Huang G, Wan X, Korteweg C and Gu J. Immunoglobulin G Expression and its Potential Role in Primary and Metastatic Breast Cancers. Current Molecular Medicine, 2013, 13(3):429-437.

24.Chen HW, Du CW, Wei XL, Khoo US, Zhang GJ#. Cytoplasmic CXCR4 high-expression exhibits distinct poor clinicopathological characteristics and predicts poor prognosis in triple-negative breast cancers. Current Molecular Medicine, 2013, 13(3):410-6.

25.Zhang GJ*, Chen TB, Joseph D, Tao WK, Vanko A, Connolly B, David L. Williams J, Cyrille S. Visualization of Mitotic Arrest of Cell Cycle with Bioluminescence Imaging in Living Animals. Molecular Imaging and Biology, 2013, 15(4):431-40.

26.Peng X, Chen SF, Du CW, Yang P, Liang SX, Zhang GJ, Dong X, Man K. Clinical features and prognostic factors in patients with nasopharyngeal carcinoma relapse after primary treatment. Head Neck Oncol, 2013, 5(2):21.

27.Chen ZH, Zhao RJ, Li RH, Guo CP, Zhang GJ#. Bioluminescence Imaging of DNA Synthetic Phase of Cell Cycle in Living Animals. PLoS one, 2013, 8(1): e53291.

28.Liu J, Wei XL, Huang WH, Chen CF, Bai JW, Zhang GJ#. Cytoplasmic Skp2 expression is associated with p-Akt1and predicts poor prognosis in human breast carcinomas. PLoS one, 2012, 7(12):e52675.

29.Du CW, Yang P, Zhang GJ, Hong C, Chen J, Dong X. Effect of arsenic trioxide on Epstein–Barr virus latent membrane protein 1-mediated E-cadherin silencing in nasopharyngeal carcinoma. Head Neck Oncol, 2012, 4(2):55.

30.Du CW, Kimijima I, Otake T, Abe R, Takenoshita S, Zhang GJ#. Down-regulation of p73 correlates with high histological grade in Japanese with breast carcinomas. Chinese Medical Journal. 2011, 124(15):2275-8.


陈敏(英文,#:通讯作者,##:并列通讯作者,*:第一作者或并列第一作者)

1.Lee HS, Chen M*, Kim JH, Kim WH, Ahn S, Maeng K, Allegra CJ, Kaye FJ, Hochwald SN, Zajac-Kaye M. Analysis of 320 gastroenteropancreatic neuroendocrine tumors identifies TS expression as independent biomarker for survival. Int J Cancer, 2014,135(1):128-37.

2.Chen M*, Shabashvili D, Nawab A, Yang SX, Dyer LM, Brown KD, Hollingshead M, Hunter KW, Kaye FJ, Hochwald SN, Marquez VE, Steeg P, Zajac-Kaye M. DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer. Molecular cancer therapeutics, 2012, 11(2):370-82.

3.Chen M*, Voeller D, Marquez VE, Kaye FJ, Steeg PS, Giaccone G, Zajac-Kaye M. Enhanced growthinhibition by combined DNA methylation/HDAC inhibitors in lung tumor cells with silenced CDKN2A. International journal of oncology, 2010, 37(4):963-71.

4.Kummar S, Gutierrez ME, Gardner ER, Chen X, Figg WD, Zajac-Kaye M, Chen M, Steinberg SM, Muir CA, Yancey MA, Horneffer YR, Juwara L, Melillo G, Ivy SP,Merino M, Neckers L, Steeg PS, Conley BA, Giaccone G, Doroshow JH, Murgo AJ. Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies. Eur J Cancer, 2010, 46(2):340-7.


李瑶琛(英文,#:通讯作者,##:并列通讯作者,*:第一作者或并列第一作者)

1.Jian Q, Tao Z, Li YC#, Zheng Q, Yin ZQ. Acute retinal injury and the relationship between nerve growth factor, Notch1 transcription and short-lived dedifferentiation transient changes of mammalian Müller cells. Vision Research, 2015, 110(Pt A):107-17.

2.Jian Q, Li YC #, Yin ZQ. Rat BMSCs initiate retinal endogenous repair through NGF/TrkA signaling. Experimental Eye Research, 2015, 132:34-47

3.Liang SX, Peng X, Li XL, Yang P, Xie LH, Li YC, Du CW##, Zhang GJ##. Silencing of CXCR4 sensitizes triple-negative breast cancer cells to cisplatin. Oncotarget, 2015, 6(2):1020-1030.

4.Natarajan S*, Li YC*. Notch1 induced brain tumor models the sonic hedgehog subgroup of human medulloblastoma. Cancer Research, 2013, 73(17):5381-90.(此论著被国际知名论文索引MDLinx网站评为具有代表性的文章)

5.Li YC*, Hibbs MA, Gard AL, Shylo NA, Yun K. Genome-wide Analysis of N1ICD/RBPJ Targets in vivo Reveals Direct Transcriptional Regulation of Wnt, SHH, and Hippo Pathway Effectors by Notch1. Stem cell, 2012, 30(4):741-52.

6.Tao Z, Dai J, He J, Li C, Li YC#, Yin ZQ.The Influence of NaIO3-Induced Retinal Degeneration on Intra-retinal Layer and the Changes of Expression Profile/Morphology of DA-ACs and mRGCS. Mol Neurobiol, 2013, 47(1):241-60.

7.Wang YH, Li YC*, Huo SJ, Yin ZQ. Alpha-crystallin promotes rat olfactory ensheathing cells survival and proliferation through regulation of PI3K/Akt/mTOR signaling pathways. Neurosci Lett, 2012, 531(2):170-5.

8.Zhao T, Li YC*, Weng C, Yin Z. The changes of potassium currents in RCS rat Müller cell during retinal degeneration. Brain Res, 2012, 1427:78-87.

9.Li YC*, Li C, Chen Z, He J, Tao Z, Yin ZQ. A MicroRNA, mir133b, suppresses melanopsin expression mediated by failure dopaminergic amacrine cells in RCS rats. Cell Signal, 2012, 24(3):685-98.

10.Huo SJ, Li YC*, Xie J, Li Y, Raisman G, Zeng YX, He JR, Weng CH, Yin ZQ. Transplanted mixtures of olfactory ensheathing cells and olfactory nerve fibroblasts reduce retinal degeneration in Royal College of Surgeons rats. Curr Eye Res, 2012, 37(8):749-58.


崔玉坤(英文,#:通讯作者,##:并列通讯作者,*:第一作者或并列第一作者)

1.Hong C, Zhang F, You Y, Qiu W, Giuliano A, Cui X, Zhang G, Cui Y#. Elevated C1orf63 expression is correlated with CDK10 and predicts better outcome for advanced breast cancers: a retrospective study. BMC Cancer, 2015, 15:548.

2.Pan H, Jiang Q, Yu Y, Mei J, Cui Y#, Zhao WJ. Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin via the AKT andERK signalling pathways in human glioma cells. Neurochem Int, 2015, 80:60-71.

3.Li G, Zhao F, Cui Y#. Proteomics using mammospheres as a model system to identify proteins deregulated in breast cancer stem cells. Curr Mol Med,2013,13(3):459-63.


杜彩文(英文,#:通讯作者,##:并列通讯作者,*:第一作者或并列第一作者)

1.Zhang YQ, Wei XL, Liang YK, Chen WL, Zhang F, Bai JW, Qiu SQ, Du CW, Huang WH##, Zhang GJ##. Over-Expressed Twist Associates with Markers of Epithelial Mesenchymal Transition and Predicts Poor Prognosis in Breast Cancers via ERK and Akt Activation. PLoS One, 2015, 10(8):e0135851.

2.He DE, Bai JW, Liu J, DU CW, Huang WH, Zhang GJ#. Clinicopathological characteristics and prognosis of breast cancer patients with type 2 diabetes mellitus. Mol Clin Oncol, 2015,3(3):607-612.

3.Wei XL, Dou XW, Bai JW, Luo XR, Qiu SQ, Xi DD, Huang WH, Du CW, Man K, Zhang GJ#. ERα inhibits epithelial-mesenchymal transition by suppressing Bmi1 in breast cancer. Oncotarget, 2015, 6(25):21704-17.

4.Liang SX, Peng X, Li XL, Yang P, Xie LH, Li YC, Du CW##, Zhang GJ##. Silencing of CXCR4 sensitizes triple-negative breast cancer cells to cisplatin. Oncotarget, 2015, 6(2):1020-1030.

5.Huang WH, Qiu SQ, Wu JD, Du CW, Cui YK and Zhang GJ*. Analysis of Clinicopathological Characteristics and Prognosis of 1425 Primary Breast Cancer Patients in Eastern Guangdong, China. Current Signal Transduction Therapy, 2014, 9(1):44-49.

6.Wei JT, Huang WH, Du CW, QIU SQ, Wei XL, Liu J, Zhang GJ#. Clinicopathological features and prognostic factors of young breast cancers in Eastern Guangdong of China. Scientific Reports, 2014, 4:5360.

7.Yang P, Liang SX, Huang WH, Zhang HW, Li XL, Xie LH, Du CW##, Zhang GJ##. Aberrant expression of CXCR4 significantly contributes to metastasis and predicts poor clinical outcome in breast cancer. Current Molecular Medicine. 2014, 14(1):174-84.

8.Chen SF, Du CW##, Yang P, Zhang HW, Man K and Zhang GJ##. The molecular and clinicopathologic characteristics of bilateral breast cancer. Scientific Reports, 2013, 3:2590.

9.Yang P, Du CW##, Man K, Liang SX and Zhang GJ##. The impact of p53 in predicting clinical outcome of breast cancer patients with visceral metastasis. Scientific Reports, 2013,3:2246.

10.Chen HW, Du CW*, Wei XL, Khoo US, Zhang GJ#. Cytoplasmic CXCR4 high-expression exhibits distinct poor clinicopathological characteristics and predicts poor prognosis in triple-negative breast cancers. Current Molecular Medicine, 2013, 13(3):410-6.

11.Peng X, Chen SF, Du CW#, Yang P, Liang SX, Zhang GJ, Dong X, Man K. Clinical features and prognostic factors in patients with nasopharyngeal carcinoma relapse after primary treatment. Head Neck Oncol, 2013, 5(2):21.

12.Du CW*, Yang P, Zhang GJ, Hong C, Chen J, Dong X. Effect of arsenic trioxide on Epstein–Barr virus latent membrane protein 1-mediated E-cadherin silencing in nasopharyngeal carcinoma. Head Neck Oncol, 2012, 4(2):55.

13.Du CW*, Kimijima I, Otake T, Abe R, Takenoshita S, Zhang GJ#. Down-regulation of p73 correlates with high histological grade in Japanese with breast carcinomas. Chinese Medical Journal. 2011, 124(15):2275-8.



(二)所获奖项

汕头市科学技术进步奖,项目名称:乳腺癌转移进展机制及预后研究,奖励等级:一等奖,获奖者:张国君、杜彩文、刘静、崔玉坤、黄文河、魏晓龙、陈宏武、许宏武、马长春。

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