研究成果&代表性论文

 

研究成果

(1)2001年获得国家发明专利1项:具有心血管活性的氟哌啶醇季铵盐衍生物.
(专利号:ZL 96 1 19098.1.)

(2)项目《碘化N-正丁基氟哌啶醇抗心肌缺血的作用与机理》2004年获得国际奖励新药开发的第五届国际德彪-CCRF中国奖二等奖

(3)项目《氟哌啶醇季胺盐衍生物F2抗心肌缺血的作用与机理》2007年获得广东省科学技术奖一等奖

(4)项目《氟哌啶醇季胺盐衍生物F2抗心肌缺血的作用与机理》2004年获得汕头市科技进步一等奖

(5)项目《革兰阴性杆菌β-内酰胺酶的系列研究》2003年获得重庆市科技进步三等奖

 

代表性论文

1.Zhongjie Huang, a Yicun Chen, b Daojun Liu,* c Chao Lu, c Zhiwei Shen, d Shuping Zhong e and Ganggang Shi * b.Gadolinium-conjugated star-block copolymer polylysine-modi?ed polyethylenimine as high-performance T1 MR imaging blood pool contrast agents.RSC Advances.

2.Sun T, Zhang Y, Zhong S, Gao F, Chen Y, Wang B, Cai W, Zhang Z, Li W, Lu S, Zheng F, Shi G. N-n-Butyl Haloperidol Iodide, a Derivative of the Anti-psychotic Haloperidol, Antagonizes Hypoxia/Reoxygenation Injury by Inhibiting an Egr-1/ROS Positive Feedback Loop in H9c2 Cells. Front Pharmacol. 2018 Jan 25;9:19.

3.Yan Z, Shen D, Liao J, Zhang Y, Chen Y, Shi G, Gao F. Hypoxia Suppresses TGF-B1-Induced Cardiac Myocyte Myofibroblast Transformation by Inhibiting Smad2/3 and Rhoa Signaling Pathways. Cell Physiol Biochem.2018;45(1):250-257.

4.Tang L; Chen YC; Jiang ZB ; Zhong SP ; Chen WZ; Chen WD ; Zhuang YJ ; Shi GG. PHYTOCHEMICAL INVESTIGATION OF THE MARINE ALGA Grateloupia livida.CHEMISTRY OF NATURAL COMPOUNDS. 卷: 53 期: 4 页: 770-774 .JUL 2017.

5.Lu S, Zhang Y, Zhong S, Gao F, Chen Y, Li W, Zheng F, Shi G. N-n-butyl Haloperidol Iodide Protects against Hypoxia/Reoxygenation Injury in Cardiac Microvascular Endothelial Cells by Regulating the ROS/MAPK/Egr-1 Pathway. Front Pharmacol. 2017 Jan 5;7:520.

6.Niu Y, Xu M, Slagle BL, Huang H, Li S, Guo GL, Shi G, Qin W, Xie W. Farnesoid X receptor ablation sensitizes mice to hepatitis b virus X protein-induced hepatocarcinogenesis. Hepatology. 2017 Mar;65(3):893-906.

7.Shen HM, Chen C, Jiang JY, Zheng YL, Cai WF, Wang B, Ling Z, Tang L, Wang YH, Shi GG. The N-butyl alcohol extract from Hibiscus rosa-sinensis L. flowers enhances healing potential on rat excisional wounds. J Ethnopharmacol. 2017 Jan 11. pii: S0378-8741(17)30133-2.

8.Tang L, Chen Y, Jiang Z, Zhong S, Chen W, Zheng F, Shi G. Purification, partial characterization and bioactivity of sulfated polysaccharides from Grateloupia livida. Int J Biol Macromol. 2017 Jan;94(Pt A):642-652.

9.Bai X, Yang P, Zhou Q, Cai B, Buist-Homan M, Cheng H, Jiang J, Shen D, Li L, Luo X, Faber KN, Moshage H, Shi G.The protective effect of the natural compound hesperetin against fulminant hepatitis in vivo and in vitro. Br J Pharmacol. 2017 Jan;174(1):41-56.

10.Shi G, Zhong S. Alcohol-associated cancer and deregulation of Pol III genes.Gene. 2016 Sep 30. pii: S0378-1119(16)30793-4.

11.Cai C, Chen Y, Zhong S, Zhang Y, Jiang J, Xu H, Shi G.Synergistic Effect of Compounds from a Chinese Herb: Compatibility and Dose Optimization of Compounds from N-Butanol Extract of Ipomoea stolonifera.Scientific Repores.2016 Jun 3;6:27014.

12.Lu B, Wang B, Zhong S, Zhang Y, Gao F, Chen Y, Zheng F, Shi G. N-n-butyl haloperidol iodide ameliorates hypoxia/reoxygenation injury through modulating the LKB1/AMPK/ROS pathway in cardiac microvascular endothelial cells. Oncotarget. 2016 Jun 7;7(23):34800-10.

13.Chen YC, Zhu W, Zhong SP, Zheng FC, Gao FF, Zhang YM, Xu H, Zheng YS, Shi GG. Characterization and bioactivity of novel calcium antagonists - N-methoxy-benzyl haloperidol quaternary ammonium salt. Oncotarget. 2015 Oct 19.

14.Ye DY, Jiang ZB, Zheng FC, Wang HM., Zhang YM, Gao FF, Chen PH, Chen YC, Shi GG. Optimized Extraction of Polysaccharides from (Harv.) Yamada and Biological Activities. Molecules. 2015; 20(9): 16817-16832.

15.Wang B, Zhong SP, Zheng FC, Zhang YM, Gao FF, Chen YC, Lu BE, Xu H, Shi GG. N-n-butyl haloperidol iodide protects cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy. Oncotarget. 2015; 6(28): 24709-24721.

16.Zhang YM, Liao H, Zhong SP, Gao FF, Chen YC, Huang ZQ, Lu SS, Sun T, Wang B, Li WQ, XuH, Zheng FC, Shi GG. Effect of N-n-butyl haloperidol iodide on ROS/JNK/Egr-1 signaling in H9c2 cells after hypoxia/reoxygenation. SCIENTIFIC REPORTS. 2015; 5: 11809: 1-11.

17.Huang YP, Gao FF, Wang B, Zheng FC, Zhang YM, Chen YC, Huang ZQ, Zhong SP, Shi GG. N-n-butyl haloperidol iodide inhibits H2O2-induced Na+/Ca2+-exchanger activation via the H+ exchanger in rat ventricular myocytes. Drug Design, Development and Therapy. 2014; 8: 1257–1267.

18.Yuan RF, Zheng FC, Zhong SP, Tao XJ, Zhang YM, Gao FF, Yao F, Chen JX, Chen YC, Shi GG. Self-Assembled Nanoparticles of Glycyrrhetic Acid-Modified Pullulan as a Novel Carrier of Curcumin. Molecules. 2014;19(9):13305-13318.

19.Cai CY, Chen YC, Zhong SP, Ji B, Wang JZ, Bai XT, Shi GG. Anti-Inflammatory Activity of N-Butanol Extract from Ipomoea stolonifera In Vivo and In Vitro. PloS one. 2014; 9(4): e95931.

20.Niu Y, Wang Z, Huang H, Zhong S, Cai W, Xie Y, Shi GG. Activated pregnane X receptor inhibits cervical cancer cell proliferation and tumorigenicity by inducing G2/M cell-cycle arrest. Cancer Lett. 2014; 347: 88-97.

21.Jiang ZB, Chen YC, Yao F, Chen WZ, Zhong SP, Zheng FC, Shi GG. Antioxidant, Antibacterial and Antischistosomal Activities of Extracts from Grateloupia livida (Harv). Yamada. PLoS ONE 2013; 8(11): e80413.

22.Zhang YM, Chen GY, Zhong SP, Zheng FC, Gao FF, Chen YC, Huang ZQ, Cai WF, Li WQ, Liu XP, Zheng YS, Xu H, Shi GG. N-n-Butyl Haloperidol Iodide Ameliorates Cardiomyocytes Hypoxia/Reoxygenation Injury by Extracellular Calcium-Dependent and - ndependent Mechanisms. Oxidative Medicine and Cellular Longevity. 2013; Article ID 912310, 12 pages.

23.Zheng JJ, Chen YC , Yao F, Chen WZ, Shi GG. Chemical Composition and Antioxidant/Antimicrobial Activities in Supercritical Carbon Dioxide Fluid Extract of Gloiopeltis tenax. Marine Drugs. 2012; 10: 2634-2647.

24.Tao XJ, Zhang QF, Ling K, Chen YC, Yang WZ, Gao FF, Shi GG. Effect of Pullulan Nanoparticle Surface Charges on HSA Complexation and Drug Release Behavior of HSA-Bound Nanoparticles. PLoS ONE. 2012; 7(11): e49304.

25.Zhang YM, Wang CY, Zheng FC, Gao FF, Chen YC, Huang ZQ, Xia ZY, Irwin MG, Li WQ, Liu XP, Zheng YS, Xu H, Shi GG. Effects of N-n-butyl haloperidol iodide on the rat myocardial sarcoplasmic reticulum Ca(2+)-ATPase during ischemia/reperfusion. Biochem Biophys Res Commun 2012 Aug 24; 425(2): 426-430.

26.Huang Y, Gao F, Zhang Y, Chen Y, Wang B, Zheng Y, Shi G. N-n-Butyl haloperidol iodide inhibits the augmented Na(+)/Ca(2+) exchanger currents and L-type Ca(2+) current induced by hypoxia/reoxygenation or H(2)O(2) in cardiomyocytes. Biochem Biophys Res Commun. 2012 Apr 27; 421(1):86-90.

27.Peng Q, Zhou S, Yao F, Hou B, Huang Y, Hua D, Zheng Y, Qian Y. Baicalein suppresses the SOS response system of Staphylococcus aureus induced by ciprofloxacin. Cell Physiol Biochem 2011; 28(5): 1045-1050.

28.Xue-Ting Bai,Yi-Cun Chen,Wei-Zhou Chen,Hua-Ping Lei,Fen-Fei Gao,Yong-Jie Qin,Jiao-Jiao Zheng,Gang-Gang Shi. The effect of black coral extraction on acute lung inflammation induced by cigarette smoke in mice. Exp Lung Res. 2011 Dec; 37(10): 627-632.

29.Chen Yicun, Zheng Jinhong, Zheng Fuchun, Wang Jinzhi, Zhang Yanmei, Gao Fenfei, Huang Zhanqin, Shi Ganggang. Design, Synthesis, and Pharmacological Evaluation of Haloperidol Derivatives as Novel Potent Calcium Channel Blockers with Vasodilator Activity. PLoS ONE 2011; 6(11): e27673.

30.Jian-Feng Xiao, Chun-Yan Wang, Yong-Pan Huang, Jian-Xin Shen, Fen-Fei Gao, Zhan-Qin Huang, Yan-Shan Zheng, Gang-Gang Shi. N-n-Butyl Haloperidol Iodide Preserves Cardiomyocyte Calcium Homeostasis during Hypoxia/Ischemia. Cell Physiol Biochem. 2011; 27: 433-442.

31.Xueting Bai, Yicun Chen, Weizhou Chen, Huaping Lei, Ganggang Shi. Volatile Constituents, Inorganic Elements and Primary Screening of Bioactivity of Black Coral Cigarette Holders. Mar. Drugs. 2011; 9: 863-878.

32.Huang F, Li S, Lu X, Liu A, Du G, Shi G. Two glutathione S-transferase inhibitors from Radix Angelicae sinensis. Phytother Res. 2011; 25(2):284-289.

33.Gao FF, Hao SY, Huang ZQ, Zhang YM, Zhou YQ, Chen YC, Liu XP, Shi GG. Cardiac electrophysiological and antiarrhythmic effects of N-n-butyl haloperidol iodide. Cell Physiol Biochem. 2010; 25(4-5):433-442.

34.Yanqiong Zhou, Yanmei Zhang, Fenfei Gao, Fuxiao Guo, Jinzhi Wang, Wenfeng Cai, Yicun Chen, Jinhong Zheng, Ganggang Shi. N-n-butyl Haloperidol Iodide Protects Cardiac Microvascular Endothelial Cells From Hypoxia/Reoxygenation Injury by Down-Regulating Egr-1 Expression. Cell Physiol Biochem. 2010; 26(6):839-848.

35.Zhou Y, Shi G, Zheng J, Huang Z, Gao F, Zhang Y, Guo F, Jia Q, Zheng Y. The protective effects of Egr-1 antisense oligodeoxyribonucleotide on cardiac microvascular endothelial injury induced by hypoxia-reoxygenation. Biochem Cell Biol. 2010 Aug; 88(4):687-695.

36.Wang JZ, Cai CY, Zhang YM, Zheng JH, Chen YC, Li WQ, Shi GG. N-n-Butyl haloperidol iodide protects against hypoxia/reoxygenation-induced cardiomyocyte injury by modulating protein kinase C activity. Biochem Pharmacol. 2010 May 15; 79(10):1428-1436.

37.Peng, Q, Y. Huang, et al. Green tea extract weakens the antibacterial effect of amoxicillin in methicillin-resistant Staphylococcus aureus infected mice. Phytother Res 2010; 24(1): 141-145.

38.Qing Peng, Bing Hou, et al. Staphylococcal cassette chromosome mec (SCCmec) analysis and antimicrobial susceptibility profiles of methicillin-resistant Staphylococcus aureus (MRSA) isolates in a teaching hospital, Shantou, China. African Journal of Microbiology Research 2010; 4(9): 844-848.

39.Chen Y, Zheng J, Zhang Y, Wang J, Liu Q, Huang Z, Gao F, Zhou Y, Shi G. N-4-tert-butyl benzyl haloperidol chloride suppresses Ca2+-dependent Egr-1 expression and subsequently inhibits vascular smooth muscle cell proliferation induced by angiotensin II. Cell Physiol Biochem. 2009; 23(4-6):295-304.

40.Huang Z, Li H, Guo F, Jia Q, Zhang Y, Liu X, Shi G.Egr-1, the potential target of calcium channel blockers in cardioprotection with ischemia/reperfusion injury in rats. Cell Physiol Biochem. 2009; 24(1-2):17-24.

41.Yan LP, Zhuang YL, Chan SW, Chen SL, Shi GG. Analysis of the mechanisms underlying the endothelium-dependent antivasoconstriction of puerarin in rat aorta. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jun; 379(6):587-597.

42.Gao FF, Jia QY, Guo FX, Zhang YM, Huang ZQ, Zhou YQ, Chen YC, Shi GG. Egr-1, a central and unifying role in cardioprotection from ischemia-reperfusion injury? Cell Physiol Biochem. 2009; 24(5-6):519-526.

43.Huang F, Xu L, Ganggang Shi. Antioxidant isolated from Schisandra propinqua (Wall.) Baill. Biol Res. 2009; 42(3): 351-356.

44.Gao FF, Shi GG, Zhou YQ, Liu XP. Reformative cannula electrodes for his bundle electrogram recording in isolated rat hearts. Chinese Journal of Pysiology. 2008; 51(2): 116-119.

45.Zhang Y, Shi G, Zheng J, Lv Y, Gao P, Huang Z, Gao F, Zhou Y. The protective effect of Egr-1 antisense oligodeoxyribonucleotide on myocardial injury induced by ischemia-reperfusion and hypoxia-reoxygenation. Cell Physiol Biochem.2008; 22(5-6):645-652.

46.Zhang Y, Shi G, Zheng J, Tang Z, Gao P, Lv Y, Guo F, Jia Q. The protective effects of N-n-butyl haloperidol iodide on myocardial ischemia-reperfusion injury in rats by inhibiting Egr-1 overexpression. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY. 2007; 20(5): 639-648.

47.Huang Z, Shi G, Gao F, Zhang Y, Liu X, Christopher TA, Lopez B, Ma X. Effects of N-n-butyl haloperidol iodide on L-type calcium channels and intracellular free calcium in rat ventricular myocytes. Biochemistry and Cell Biology. 2007; 85(2): 182-188.

48.Yao, F., Y. Qian, et al. Incidence of extended-spectrum beta-lactamases and characterization of integrons in extended-spectrum beta-lactamase-producing Klebsiella pneumoniae isolated in Shantou, China. Acta Biochim Biophys Sin (Shanghai) 2007; 39(7): 527-532.

49.Yan-Mei ZHANG,Gang-Gang Shi, et al. Effects of N-n-butyl Haloperidol Iodide on Myocardial Ischemia/Reperfusion Injury and Egr-1 Expression in rats. Acta Biochimica et Biophysica Sinica. 2006; 38(6):435-441.

50.Fen-Fei Gao, Gang-Gang Shi, Jin-Hong Zheng, et al. Protective Effects of N-n-butyl Haloperidol Iodide on Myocardial Ischemia-Reperfusion Injury in Rabbits. Chinese Journal of Physiology. 2004; 47:61-66.

51.Hong Ding, Jing Tong, Shi-Cheng Wu, Deng-Ke Yin, Xian-Fen Yuan, Jian-Yuan Wu, Jun Chen, Gang-Gang Shi. Modulation of Kupffer cells onhepatic drug metabolism. World Journal of Gastroenterology. 2004; 10(9):1325-1328.

52.Huang ZQ, Shi GG, et al. Effects of N-n-butyl haloperidol iodide on rat myocardial ischemia and reperfusion injury and L-type calcium current. Acta Pharmacologica Sinica. 2003; 24(8):757-763.

53.Hong Ding, Gang-Gang Shi, et al. Modulation of GDCL3 and Angelica Sinensis polysaccharides on differentially expressed genes in liver of hepatic immunological injury mice by cDNA microarray. World Journal of Gastroenterology. 2003; 9(5):1072-1076.

54.Shi GG, Fang F, et al. Quaternary ammonium salt derivative of haloperidol inhibits KCl-induced calcium increase in rat aortic smooth muscle cells. Acta Pharmacologica Sinica. 2001; 22(9): 837-840.

55.Shi GG, Wei DS, et al. Effect of phencyclidine on dog coronary artery. Acta Pharmacologica Sinica. 1996; 17(3):224-226.

56.Shi GG, Xu SF, et al. Effect of phencyclidine on contraction of porcine coronary vessel strips. Acta Pharmacologica Sinica. 1993; 14(3): 211-213.

57.Shi GG, Xu SF,et al. Phencyclidine receptors in porcine coronary artery. Acta Pharmacologica Sinica. 1993; 14 (1): 39-41.

58.Huang ZQ, Shi GG, et al. Effects of N-n-butyl haloperidol iodide on L-type calcium channel in rat ventricular myocytes. Acta Pharmacologica Sinica. 2006; 27: 196-196. (Abstract)

59.ZHANG Yan-Mei,Gang-Gang Shi, et al. Effects of N-n-butyl Haloperidol Iodide on Myocardial Ischemia/Reperfusion Injury and Egr-1 Expression in Rat. Acta Pharmacologica Sinica. 2006; 27:140-140. (Abstract)

60.Zhou YQ, Shi GG, et al. Protective effects of N-n-butyl haloperidol iodide on myocardial ischemia-reperfusion injury in rats. Acta Pharmacologica Sinica. 2006; 27: 140-140. (Abstract)

61.Fen-Fei Gao,Gang-Gang Shi, et al.,Effects of N-n-butyl haloperidol iodide on transient outward potassium current in rat ventricular myocytes. Drug Development Research. 2005; 66(3):231-231. (Abstract)

62.Yin j, Shi GG, Wang HL. Effects of leonurus heterophyllus sweet on haemorheology and thrombosis on rat with myocardial ischaemia. European Heart Journal. 2003; 24: 79-79. (Abstract)

XML 地图 | Sitemap 地图